The Intracellular Dynamics of Hiv

Grant number: 1025567 | Funding period: 2012 - 2014

Completed

Abstract

HIV infection is a dynamic process, in which the host immune response tries to control viral growth and keep up with the rapid evolution of the virus. This project assembles an interdisciplinary team of mathematicians and biologists to use a modelling approach to understand the dynamics of viral infection, viral evolution, and immune control in the infected individual. The insights gained from this project will help in the development of new drug and vaccination strategies.

Related publications (3)

Relationship between measures of HIV reactivation and decline of the latent reservoir under latencyreversing agents

J Petravic, TA Rasmussen, SR Lewin, SJ Kent, MP Davenport

2017-05-01

Antiretroviral-free HIV remission requires substantial reduction of the number of latently infected cells and enhanced immune cont..

Epitope-specific CD8 T cell kinetics rather than viral variability determine the timing of immune escape in simian immunodeficiency virus infection

AP Martyushev, J Petravic, AJ Grimm, H Alinejad-Rokny, SL Gooneratne, JC Reece, D Cromer, SJ Kent, MP Davenport

2015-05-01

CD8<sup>+</sup> T cells are important for the control of chronic HIV infection. However, the virus rapidly acquires "escape mutati..

Trivalent live attenuated influenza-simian immunodeficiency virus vaccines: Efficacy and evolution of cytotoxic T lymphocyte escape in macaques

JC Reece, S Alcantara, S Gooneratne, S Jegaskanda, T Amaresena, CS Fernandez, K Laurie, A Hurt, SL O'Connor, M Harris, J Petravic, A Martyushev, A Grimm, MP Davenport, J Stambas, R De Rose, SJ Kent

2013-04-01

There is an urgent need for a human immunodeficiency virus (HIV) vaccine that induces robust mucosal immunity. CD8<sup>+</sup> cyt..

University of Melbourne Researchers

Rob De Rose